| Abstrakt: |
Objectives: Prediabetes is recognized as a significant metabolic status, being a key factor in the occurrence of diabetes mellitus (DM). There is increasing evidence concerning microvascular complications in prediabetes most commonly in skin, kidneys and retina (1,2). Laser speckle contrast analysis (LASCA) is a non-invasive technique that can be used to evaluate skin microvascular function. Previous studies have shown skin microvascular dysfunction in patients with DM (3). However, to our knowledge, no previous study has evaluated skin microcirculation, using LASCA, in patients with prediabetes. Methods: In all subjects, forearm skin blood flow was recorded under standardized conditions using a laser speckle contrast imager (PeriCam PSI NR System, Perimed). Post-occlusive reactive hyperemia (PORH) was assessed following a standardized protocol and data were analyzed with a signal processing software (PIMSoft, Perimed). The amplitude of PORH responses was expressed as a percentage increase between peak and baseline perfusion (%). Results: Twenty-nine individuals (14 patients with prediabetes and 15 controls) were studied. There wasn't any statistically significant difference regarding age, sex, body mass index and blood pressure levels between the two groups. At baseline, skin microvascular perfusion was significantly higher in patients with prediabetes compared to controls (50.9 ± 11.5 vs. 39.2 ± 8.7, p = 0.006) while during occlusion, perfusion was similarly reduced in both groups. Post occlusion reperfusion was significantly lower in the prediabetes group as compared to the controls (145.0 ± 42.8 vs. 195.2 ± 47.3% respectively, p = 0.007). Conclusions: We showed, for the first time, that individuals with prediabetes demonstrated skin microvascular dysfunction, that may reflect a more generalized microvascular damage. [ABSTRACT FROM AUTHOR] |
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