| Autor: |
Mladinić, Ema Puizina, Ercegović, Saša, Jerković, Daniel |
| Předmět: |
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| Zdroj: |
Acta Stomatologica Croatica; Dec2022, Vol. 56 Issue 4, p433-433, 1/4p |
| Abstrakt: |
Introduction: Central odontogenic fibroma (COF) is a neoplasm of the jaw consisting of fibrous connective tissue, with or without calcification, and variable amounts of inactive odontogenic epithelium. Central gigantocellular granuloma (CGCG) is a locally destructive, benign lesion of the jaw that contains osteoclast-like giant cells in a fibrovascular stroma. Hybrid lesions with histological features of COF and CGCG have been described in less than 50 cases worldwide. This lesion shows a higher recurrence rate compared to COF, thus suggesting that CGCG may be the driving force behind recurrence. Like CGCG, this neoplasm has a high preference for the lower jaw (95%). The aim of this case report is to show the therapy of hybrid lesion, which, according to the currently available literature, has been described in the upper jaw in only 2 cases. Case report: A 30-year-old female patient was administered to the Clinic for oral and maxillofacial surgery at KBC Split due to bulging of the left side of the upper jaw. A clinical examination revealed a palpable hard, painless swelling. Radiographic evaluation showed the presence of a well-defined unilocular radiolucent area around the roots of the maxillary first and second premolars. The tumor was surgically removed by enucleation and bone curettage in endotracheal anesthesia, as well as the dental implants located near the tumor affected by peri-implantitis at the location of teeth 26/27. Pathohistological verification confirmed the hybrid lesion of COF and CGCG. The patient showed no clinical or radiographic signs of recurrence one year after surgery. The nature of this lesion and its unpredictable behavior is dictated by a unique pathohistological picture with a CGCG component that leads to a higher recurrence rate, and it is successfully treated by surgical enucleation with local bone curettage. Further studies with long-term follow-up are needed to understand the pathogenesis of combined COF and CGCG lesions. [ABSTRACT FROM AUTHOR] |
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