| Autor: |
Dogan, Melike Karacam, Karakaşlı, Ahmet Alp, Özkan, Esra, Türkoğlu, Özge, Yalcinkaya, Oguz Kaan, Oytun, Merve Güner, Zengin, Hatice Yağmur, Doğu, Burcu Balam, Karaosmanoğlu, Ayça, Karahan, Sevilay, Topçuoğlu, Esen Saka, Ayhan, Yavuz |
| Zdroj: |
Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2022 Supplement 6, Vol. 18 Issue 6, p1-2, 2p |
| Abstrakt: |
Background: 25(OH)D may play role in differentiation and development of the hippocampus(1).25(OH)D deficiency was associated with reduced hippocampal volume in mild cognitive impairment(MCI)(2).We previously have shown that 25(OH)D levels were independently associated with reduced cognition independent from disease and AD‐related morphological changes(3),however the association with hippocampal subfields was not studied.We aimed to study the possible association between hippocampal subvolumes and 25(OH)D levels in our middle‐old age research participants. Method: The participants were collected from a cognitive disorders research clinic at Hacettepe University.Those who use 25(OH)D supplements at the evaluation,have renal failure or diseases that could affect 25(OH)D metabolism were excluded.Concurrent serum 25(OH)D levels,Modified Mini Mental Test(3MS) scores and brain MRI data were retrospectively analyzed.FreeSurfer v.6.0 was used for automated structural neuroimaging analysis.Desikan‐Killiany atlas was utilized and in addition to the total volumes,the volumes of 12 distinct subfields of right and left hippocampi were analysed.Volumes were normalized to total intracranial volumes.Linear regression was used to determine the factors associated with the hippocampal volumes and the hippocampal subfields.Age, gender, education(years),3MS scores,syndromic diagnoses and 25(OH)D levels were used as the independent variables.Funded by TUBITAK 214S048,Hacettepe University THD2018‐17363 and Psychiatric Association of Turkey. Result: 208 patients(54 AD,83 subjective and mild CI,71 cognitively intact)were evaluated.Mean age was 70±9. 58.7% of the sample was female.19.7% had not finished primary school.Mean 25(OH) level was 20.5±12.16 ng/ml,57% of the sample had clinical vitamin D deficiency.25(OH)D levels were not different among diagnostic groups.Cognitive scores and age were the most consistent predictors of hippocampal subfields.In the multivariate analyses there was no association between hippocampal subunits and 25(OH)D levels regardless of the diagnoses(F=0.207, df=2, p=0.813). Conclusion: Hippocampal volumes were not associated with 25(OH)D levels in line with our previous findings.This finding further support the hypothesis that vitamin D might be an independent factor for cognitive impairment.However our results differed from studies reporting positive correlation between hippocampal atrophy and 25(OH)D deficiency.This may be due to the heterogenous and limited nature of our sample,cross‐sectional nature of the study (those with previous vitamin D use were not eliminated) and the limited low range of 25(OH)D levels in our sample,consistent with the Turkish population.Further studies are needed to assess the role of 25(OH)D in neurodegeneration and cognitive decline. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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