| Autor: |
Motter, Jeffrey N, Choi, Jongwoo, Lee, Seonjoo, Goldberg, Terry E., Devanand, Davangere P. |
| Zdroj: |
Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2022 Supplement 7, Vol. 18 Issue 7, p1-4, 4p |
| Abstrakt: |
Background: Odor identification deficits predict transition to dementia, whereas intact odor identification and global cognition may identify lack of transition. The purpose of this study is to examine intact odor identification and global cognitive functioning as prognostic indicators of lack of transition to dementia in a well‐characterized biracial (Black and White) cohort. Method: In a community‐dwelling sample of 2,270 older adults without dementia participating in the Health, Aging, and Body Composition (Health ABC) study, odor identification was measured using the Cross‐Cultural Smell Identification Test (BSIT) and global cognition was measured using the Teng Modified Mini‐Mental Status Examination (3MS), both in Year 3. Incident dementia was defined by diagnosis in medical/hospital records or prescription of anti‐Alzheimer's disease medications. Survival analyses for dementia transition over 4 years and 8 years were conducted using Cox proportional‐hazards models. Result: Survival analyses adjusted for demographic and medical covariates indicated that impaired odor identification (hazard ratio [HR] = 2.17, 95% confidence interval [CI] = 1.5‐3.1) and global cognition (HR = 2.75, 95% CI = 1.8‐4.3) each independently predicted transition to dementia (n = 287). Odor identification interacted with ApoE genotype, such that the effect of impaired odor identification on dementia transition risk was significantly greater in ApoE e4 carriers (HR = 4.0) than noncarriers (HR = 1.6). This interaction was significant for White participants, though not for Black participants. Among participants with intact odor identification (BSIT ≥ 11/12 correct) and global cognition (3MS ≥ 77/100 correct), 6.4% (49/765) transitioned to dementia over 8 years of follow‐up. Only 0.9% (4/451) of participants aged 70–75 with intact performance on both measures transitioned to dementia over 4 years of follow‐up. Conclusion: Odor identification testing paired with global cognitive screening identified individuals at low risk for transition to dementia in a biracial community cohort with this decrease in risk being pronounced in the seventh to eighth decade of life. Identification of such individuals can obviate the need for extensive investigation to establish a diagnosis and has potential for screening participants for clinical trials. [ABSTRACT FROM AUTHOR] |
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