| Autor: |
Chappelle, Sheridan D., Gigliotti, Christina, Leger, Gabriel C., Peavy, Guerry M., Jacobs, Diane M., Banks, Sarah J, Little, Emily A, Galasko, Douglas R., Salmon, David P. |
| Zdroj: |
Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2022 Supplement 7, Vol. 18 Issue 7, p1-3, 3p |
| Abstrakt: |
Background: The number of Americans with Alzheimer's disease (AD) is expected to rise to nearly 14 million by 2060. This alarming number shows a critical need for brief mental status tests that can be administered remotely (e.g., by telephone or videoconferencing) to large numbers of individuals while maintaining the ability to reliably detect cognitive impairment related to AD. Therefore, we sought to validate a recently developed, remotely administered cognitive screening measure, the T‐MoCA, against an established remote measure, the TICS, and prior in‐person clinical and cognitive assessment that provided clinical diagnosis. Relationships with CSF biomarkers of AD were also examined. Methods: The TICS and T‐MoCA were completed approximately one‐week apart by 215 participants at the UCSD ADRC. Test order was partially counterbalanced. Extensive in‐person clinical and neuropsychological assessment had been completed on average 1.5 years prior and participants classified as cognitively normal (CN; n = 167), mild cognitive impairment (MCI; n = 25) or dementia (n = 23). CSF had been obtained from 79 participants within 48 months of remote testing and levels of Aβ 1–40 and 1–42, phosphorylated tau (p‐tau), and total tau were measured. Results: TICS and T‐MoCA scores were highly correlated overall (r =.787;p<.001), and moderately within specific MCI (r =.657;p<.001) and dementia (r =.673,p =.001) groups (r =.309, p<.001 for CN only). Groups differed significantly on TICS (F(2,212) = 156.66;p<.001) and T‐MoCA (F(2,210) = 143.72;p<.001), with dementia
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