| Abstrakt: |
Background: Three subtypes of prodromal dementia with Lewy bodies (DLB) have recently been proposed. This study investigates the frequency of symptoms in the prodromal phase of DLB. Method: Patients diagnosed with DLB between the 1st of February 2017 and 1st of February 2021 were retrospectively identified and matched to a group of patients with Alzheimer's disease (AD). Patient case files were reviewed identifying the first symptoms and symptoms in the prodromal phase (cognitive impairment, psychiatric symptoms, delirium/acute confusional episodes, RBD, motorsymptoms indicative of Parkinson's disease, anosmia, and autonomic dysfunction). Results: A retrospective cohort of 166 DLB patient and 168 AD patients were included. Of the proposed subtypes in patients diagnosed with DLB, 30% presented with cognitive impairment at onset in isolation, 6% with psychiatric symptoms, and 2% with delirium/acute confusional episodes (Figure). Eighty‐three percent of DLB patients had two or more non‐cognitive symptoms in the prodromal phase. Further, 82 % had at least one psychiatric symptom, and 33 % had an episode with delirium/acute confusional episode in the prodromal phase. Of other possible subtypes, Rapid eye movement sleep Behaviour Disorder was found at onset in 22% with a mean prodromal length of 8.4 years (as opposed to 4.3 years in DLB generally) Conclusion: We found no supportive evidence of the proposed clinical subtypes of prodromal DLB. Our findings indicate that RBD subtypes may exist, but further research is needed. [ABSTRACT FROM AUTHOR] |
