| Autor: |
Al-Ghurabi, Batool H., Adham, Zeina S., Abbas, Ahmed A. |
| Předmět: |
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| Zdroj: |
Chemical Engineering Progress; Jun2022, Vol. 118 Issue 6, p1-7, 7p |
| Abstrakt: |
Background: Innate immunity plays an important role in deciding the severity of coronavirus disease 2019 (COVID-19) and disease outcomes. Defensins are antimicrobial peptides that are produced by epithelial cells in mucosal locations and play a key role in innate immunity. Understanding COVID-19 mucosal agents and their role in disease severity is critical for developing therapeutic options and identification of prognostic markers for COVID-19. Objective: In this study, we aimed to determine the role of b-defensin-1 in patients with COVID-19 and compare it with that of the control group, as well as to look into the link between b-defensin-1 and oral hygiene and disease severity. Methods: This case-control study included 50 patients with COVID-19 and 35 controls of similar ages and sexes. From November 2020 to January 2021, the patients were admitted to Baghdad Teaching Hospital/Medical City. The simplified oral hygiene index was used to determine oral hygiene status. Blood samples were obtained from all subjects (patients and controls), and the serum levels of bdefensin-1 were measured using enzyme-linked immunosorbent assay (ELISA). Results: Findings showed a non-significant reduction (P < 0.05) in the b-defensin-1 level among patients compared with that of the controls. In addition, patients with severe disease had a significantly lower level of b-defensin-1 than those with mild disease. There were no significant variations in the levels of b-defensin-1 between patients with good oral hygiene and those with poor oral hygiene (P < 0.05). Conclusions: The reduction in b-defensin-1 levels indicates an abnormal immune response in these patients and may require a new treatment option for this condition in the future. Furthermore, in patients with severe disease, a considerable drop in b-defensin-1 might be used as an indicator of illness severity. [ABSTRACT FROM AUTHOR] |
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