| Autor: |
Gallizia, Elena, Ferrara, Eleonora, Beldì, Debora, Zannetti, Micol, Loi, Gianfranco, Franco, Pierfrancesco, Gennari, Alessandra, Krengli, Marco |
| Zdroj: |
Reports of Practical Oncology & Radiotherapy; 2022, Vol. 27 Issue 5, p778-786, 9p |
| Abstrakt: |
Background: The present study assessed clinical outcomes of stereotactic body radiotherapy (SBRT) in oligometastatic prostate cancer patients. Materials and methods: Between 2017 and 2020, 37 lesions (12 osseous and 25 nodal targets) detected with conventional and/or functional imaging, were treated in 29 patients (pts), in different clinical settings: de novo oligometastatic (2 pts), oligorecurrent castration-sensitive (19 pts), castration-resistant (6 pts) prostate cancers and oligoprogressive disease during systemic therapy (2 pts). SBRT was delivered with volumetric modulated arc therapy up to a total dose of 21 Gy given in 3 fractions for bone and 30 Gy in 5 fractions for nodal metastases. A total of 34% of pts received hormonal therapy. We evaluated biochemical control [prostate serum antigen (PSA) increase < 10%)], progression free-survival (PFS) (time from SBRT to biochemical progression), local control (LC) (time from SBRT to in-field radiologic progression), hormone/systemic therapy-free survival, acute and late toxicities. results: At 3 months, biochemical response was observed in 20/29 pts (69%). At a median follow-up of 17 months (range 6-33), 8/20 (40%) of the 3-month responders remained free from progression. Two-year PFS and LC were 37% and 70%, respectively. In-field progression occurred in 3/37 (8%) lesions. hormone/systemic therapy was delayed by an average of 11.6 months (range 3--28). No significant difference in PFS based on the type of lesion or concomitant endocrine therapy was observed and no toxicity > grade 2 was reported. conclusions: SBRT for oligometastatic prostate cancer offers a good biochemical/local control and tangible delay of hormone/ systemic therapy without major toxicities. [ABSTRACT FROM AUTHOR] |
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