| Autor: |
A. R., Prata, J. P., Freitas, M. L., Marques, F., Campos Cosca, M., Santiago, S., Serra, M., Coutinho, T., Santiago, J., Rovisco, J. A. P., da Silva |
| Předmět: |
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| Zdroj: |
ARP Rheumatology; Jul-Sep2022, Vol. 1 Issue 3, p197-204, 8p |
| Abstrakt: |
Objectives: Salivary glands ultrasonography has recently been shown to be useful in the diagnosis of Primary Sjögren’s Syndrome (pSS). Shear-wave elastography (SWE) is a promising tool for the quantitative assessment of tissues stiffness, but studies evaluating its role in pSS diagnosis are limited. This study aimed at investigating the diagnostic performance of SWE in pSS. Materials and Methods: Materials and Methods: Cross-sectional study including patients fulfi lling the 2016 ACR/ EULAR classifi cation criteria for pSS and healthy subjects. The four major salivary glands, assessed using salivary glands ultrasound (SGUS) B-mode scans, were rated using the Hočevar score, and shear-wave velocity (SWV) values were obtained using SWE. Intraclass-correlation coeffi cient (ICC) estimates were used to assess reliability. Cut-off values for differentiating pSS patients from healthy subjects were calculated using Receiver-Operating Characteristics (ROC) curves. Results: We included 50 pSS and 25 healthy subjects. Inter-rater reliability of SWE was moderate (ICC=0.64) and intra-rater reliability was moderate to good (ICC= 0.73 to 0.83). Total SWV (2.09 m/s (0.32); p<0.001), parotid SWV (2.25 m/s (0.40)) and submandibular SWV (1.92 m/s (0.38)) were signifi cantly higher in pSS patients. Total and parotid SWV presented good diagnostic performance for pSS diagnosis (AUROC= 0.80 and 0.81, respectively). The Hočevar score demonstrated excellent diagnostic performance (AUROC= 0.98) and combining it with total SWV did not result in statistically signifi cant improvement (p=0.301). Conclusions: SWE may contribute to the diagnosis of pSS. Large prospective studies including sicca and secondary SS patients, as well as the standardisation of SWE protocols, are warranted to assess the role of SWE in pSS management. [ABSTRACT FROM AUTHOR] |
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