| Autor: |
Soltani, Mozhgan, Etminan, Ayda, Rahmati, Amir, Behjati Moghadam, Mahsa, Ghaderi Segonbad, Ghazaleh, Homayouni Tabrizi, Masoud |
| Předmět: |
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| Zdroj: |
Materials Technology; Sep2022, Vol. 37 Issue 11, p1703-1715, 13p |
| Abstrakt: |
The aim of this survey was to fabrication of chitosan nanoparticle was loaded by Boswellia sacra essential oil (BS-CNPs) and investigation of its pharmacological activities.BS-CNPs was synthesized by ionic gelation method and characterized. BS-CNPs-mediated cell viability and cell death were studied by MTT, qPCR, AO/PI staining and flow cytometery. Anti-angiogenesis properties were evaluated by CAM and scratch assay. Anti-oxidant properties were assessed by ABTS, DPPH, FRAP and ROS assay. The BS-CNPs (80.13 nm, ζ-p 39.20 mv and %EE: 82.7%) exhibited selective cytotoxicity on HepG2 cells (IC50:62.94 μg/ml). BS-CNPs induced the apoptosis by up-regulation of P53, Cas-3 and 9. Increasing the rate of free radical scavenging and intracellular ROS confirmed the anti and pro-oxidant potential of BS-CNPs outside and inside of cancer cells.Inhibition (92.3%) of cell migration, reduction of angiogenic factors showed anti-angiogenic effects of BS-CNPs.BS-CNPs due tounique anti-cancer properties are suitable for therapeutic targets in cancer studies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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