| Autor: |
Afolabi, T. Adeniyi, Ejeromedoghene, Onome, Hussein, G. Oluwakemi, Afolabi, T. Adeleke, Oladoyinbo, Fatai O. |
| Zdroj: |
Materials Research Innovations; Aug2022, Vol. 26 Issue 5, p316-323, 8p |
| Abstrakt: |
Flunitrazepam abuse as 'date-rape' drug is on the increase. A colorimetric probe was developed by grafting cobalt nanoparticles (CoNPs) onto poly[β-(1→4)-2-amino-2-deoxy-D-glucopyranose] functionalized thymol blue (CFTB) backbone for the detection of flunitrazepam drug in human urine (ex-situ). Studies revealed an interaction between CFTB and Co with the formation of a five-membered ring chelated compound (FTIR), while high thermal stability properties were displayed by CFTB-CoNPs without any change in the composition of the material (TGA). The distribution of CoNPs showed an irregular spherical pore deposited on the surface of CFTB (SEM) in the dimension of 100 nm (TEM). The interaction between the CFTB-CoNPs probe and the flunitrazepam was due to ionic bonding between the protonated amine group in the biopolymer and the fluoro group of flunitrazepam. The highly selective and sensitive CFTB-CoNPs probe was able to detect at 1.00µg/L with an instant and distinct colour change from wine to orange. [ABSTRACT FROM AUTHOR] |
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