| Autor: |
Koay, Wei Li Adeline, Xiao, Jiayang, Temprosa, Marinella, Happ, Lindsey P., Monroe, Anne K., Castel, Amanda D., Rakhmanina, Natella Y., D'Angelo, Lawrence, Kharfen, Michael, Talwalkar, Anjali, Serlin, Michael, Kumar, Princy, Bhandaru, Vinay, Bezabeh, Tsedenia, Grover, Nisha, Mele, Lisa, Reamer, Susan, Sapozhnikova, Alla, Strylewicz, Greg, Barth, Shannon |
| Zdroj: |
AIDS Research & Human Retroviruses; Jun2022, Vol. 38 Issue 6, p451-454, 4p |
| Abstrakt: |
This study explored virological outcomes of two-drug (2DRs) and three-drug (3DRs) antiretroviral regimens in adults with HIV in the DC Cohort. We analyzed 310 treatment-experienced adults with sustained HIV RNA ≤50 copies/mL at baseline, 53 of whom switched to 2DRs and 257 continued 3DRs. Adults on 2DRs and 3DRs had similar demographics (median age 53.3 years, 76.8% cisgender male, 76.1% Black). Adults on 2DRs had more participants with ≥2 comorbidities (62.3% vs. 42.8%, p = .019), had a longer time since HIV diagnosis (median years 20.4 vs. 13.2, p = .017), and received the regimen of interest for a shorter duration (median years 1.3 vs. 3.3, p < .001) compared with adults on 3DRs. Adults receiving 2DRs had a higher, although nonsignificant, risk for virological failure (two consecutive HIV RNA ≥50 copies/mL) at 24 months follow-up than adults on 3DRs (6.7% vs. 1.7%, respectively; p = .10). Future analysis of the effectiveness of 2DRs is needed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
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