| Autor: |
Lianhe LI, Liangyu ZOU, Wenhui YUE, Chang LIU, Hongmei WANG, Hongmin WANG, Zhenlei WEN, Qinghua XIANG, Guocheng REN, Shigang GUO, Jugao FANG |
| Zdroj: |
Malaysian Journal of Pathology; Apr2022, Vol. 44 Issue 1, p53-60, 8p |
| Abstrakt: |
Introduction: Hypopharyngeal carcinoma is one kind of high malignant tumour followed by poor prognosis in head and neck carcinomas. This study aimed to detect miR-29a-3p and Cdc42 in patients with hypopharyngeal carcinoma. Materials and Methods: The expression of miR-29a-3p and Cdc42 mRNA were detected, and the correlation between miR-29a-3p/Cdc42 and clinical stages was investigated. Results: The relative expression of miR-29a-3p in stage II, III and IV hypopharyngeal carcinoma tissues was significantly lower than that of stage I (P< 0.05). The relative expression of Cdc42 mRNA in stage I, II and III tissues was significantly higher than that of stage I (P< 0.05). The expression of miR-29a-3p in hypopharyngeal carcinoma with lymph node metastasis was significantly lower than that without lymph node metastasis (P = 0.045). Conclusion: MiR-29a-3p and Cdc42 mRNA could be potential diagnostic biomarkers of hypopharyngeal carcinoma. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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