| Autor: |
Ponsanti, Khanittha, Nipaporn Ngernyuang, Benchamaporn Tangnorawich, Kesara Na-Bangchang, Kanyarat Boonprasert, Adis Tasanarong, Teerachat Saeheng, Akkaracha Hanwattanakul, Chiravoot Pechyen |
| Předmět: |
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| Zdroj: |
Journal of The Electrochemical Society; Mar2022, Vol. 169 Issue 3, p1-11, 11p |
| Abstrakt: |
This study reports an electrochemical sensor based on multiwalled carbon nanotubes/gold nanoparticles (MWCNTs/AuNPs) for detection of total hemoglobin (Hb) and glycated hemoglobin (HbA1c) in blood samples. Measurement of glycated hemoglobin percentage (%HbA1c) is crucial to the monitoring of glycemia in diabetes patients. The %HbA1c, which refers to the concentration ratio of HbA1c to total hemoglobin (Hb), has been widely used for accurate determination of stage-wise diabetes. The gold nanoparticles (AuNPs) used in the sensor were synthesized using a biological method employing passion fruit peel extracts. The resulting AuNPs are spherical with diameter approximately 18 nm, and these can be mixed with MWCNTs in various ratios to form MWCNTs/AuNPs composites. TEM imaging indicates that gold nanoparticles decorate the surface of the MWCNTs. Coating of a screen-printed carbon electrode (SPCE) with MWCNTs/AuNPs affords the novel MWCNTs/AuNPs/SPCE electrode, which exhibits a linear response over a 0.186-2.044 g dl-1 HbA1c concentration range, with the correlation value of 0.96. The electrode can reliably be utilized for detection of total Hb and HbA1c in blood samples, which highlights its promise as a reliable approach for sensitive point-of-care testing (POCT) of HbA1c in diabetes patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
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