Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methyl-pyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs.
| Autor: | Johannes, Jeffrey W., Balazs, Amber, Barratt, Derek, Bista, Michal, Chuba, Matthew D., Cosulich, Sabina, Critchlow, Susan E., Degorce, Sébastien L., Di Fruscia, Paolo, Edmondson, Scott D., Embrey, Kevin, Fawell, Stephen, Ghosh, Avipsa, Gill, Sonja J., Gunnarsson, Anders, Hande, Sudhir M., Heightman, Tom D., Hemsley, Paul, Illuzzi, Giuditta, Lane, Jordan |
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| Zdroj: | Journal of Medicinal Chemistry; 10/14/2021, Vol. 64 Issue 19, p14498-14512, 15p |
| Databáze: | Supplemental Index |
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