| Autor: |
Dhana, Klodian, Barnes, Lisa L., Liu, Xiaoran, Agarwal, Puja, Desai, Pankaja, Krueger, Kristin R., Holland, Thomas M., Halloway, Shannon, Aggarwal, Neelum T., Evans, Denis A., Rajan, Kumar B. |
| Zdroj: |
Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Apr2022, Vol. 18 Issue 4, p572-580, 9p |
| Abstrakt: |
Introduction: We investigated the role of genetic risk and adherence to lifestyle factors on cognitive decline in African Americans and European Americans. Methods: Using data from the Chicago Health and Aging Project (1993–2012; n = 3874), we defined the genetic risk based on presence of apolipoprotein E (APOE) ε4$\varepsilon 4$ allele and determined a healthy lifestyle using a scoring of five factors: non‐smoking, exercising, being cognitively active, having a high‐quality diet, and limiting alcohol use. We used linear mixed‐effects models to estimate cognitive decline by genetic risk and lifestyle score. Results: APOE ε4$\varepsilon 4$ allele was associated with faster cognitive decline in both races. However, within APOE ε4$\varepsilon 4$ carriers, adherence to a healthy lifestyle (eg., 4 to 5 healthy factors) was associated with a slower cognitive decline by 0.023 (95% confidence interval [CI] 0.004, 0.042) units/year in African Americans and 0.044 (95% CI 0.008, 0.080) units/year in European Americans. Discussion: A healthy lifestyle was associated with a slower cognitive decline in African and European Americans. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
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