A Comparison of Clinicopathological Differences and Survival Rates in Oral Squamous Cell Carcinoma between Middle Age and Old Age in Taiwan.
| Autor: | Sing-You Chen, Yung-Hsin Cheng, Yung-Yun Cheng, Kuan-Ju Lee, Li-Han Lin, Chung-Ji Liu, Chieh-Yuan Cheng |
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| Předmět: |
MOUTH tumors
ACQUISITION of data methodology CONFIDENCE intervals AGE distribution LOG-rank test HEAD & neck cancer RETROSPECTIVE studies SURGERY PATIENTS CANCER patients MEDICAL records SYMPTOMS DESCRIPTIVE statistics CHI-squared test KAPLAN-Meier estimator SQUAMOUS cell carcinoma PROPORTIONAL hazards models MIDDLE age OLD age |
| Zdroj: | International Journal of Gerontology; Jan2022, Vol. 16 Issue 1, p39-45, 7p |
| Abstrakt: | Background: It is unclear whether age plays a crucial role in the oral cancer prognosis. We aimed to compare the clinicopathological parameters, outcomes, and trends of patients aged ≥ 65 years (middle age, MA) and <65 years (old age, OA) with oral squamous cell carcinoma (OSCC). Methods: Data of 862 OSCC patients who underwent surgery at the Taipei MacKay Memorial Hospital between 1997 and 2017 were obtained. The patients were divided into MA and OA groups. Tumor size, nodal invasion, tumor location, radiotherapy status, pathological features, and prognosis were compared. The chi-square test was used for statistical analysis. We calculated the hazard ratios and 95% confidence intervals of all-cause mortality risk between the two groups. Results: Significant differences were noted in sex, tumor location, and survival rate between the groups. Sex, late-stage cancer, positive nodal invasion, and moderate differentiation significantly increased the mortality risks in the OA group compared to those in the MA group. In addition, OA group patients without diabetes mellitus (DM), perineural invasion, lymphovascular invasion, recurrence, secondary primary cancer, and distant metastases also showed a higher mortality risk than other patients. Conclusion: Aging could be a predictive prognostic factor for OSCC, particularly for tumor location and survival rate. Radiotherapy after surgery could increase the survival rate of OA patients with nodal invasion. [ABSTRACT FROM AUTHOR] |
| Databáze: | Supplemental Index |
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