| Autor: |
Hatami, Hossein, Sotgiu, Giovanni, Bostanghadiri, Narjess, Dolat Abadi, Sahel Shafiee, Mesgarpour, Bita, Goudarzi, Hossein, Battista Migliori, Giovanni, Javad Nasiri, Mohammad |
| Předmět: |
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| Zdroj: |
Brazilian Journal of Pulmonology / Jornal Brasileiro de Pneumologia; mac/abr 2022, Vol. 48 Issue 2, p1-12, 12p |
| Abstrakt: |
Objective: Multidrug-resistant tuberculosis (MDR-TB) is a life-threatening infectious disease. Treatment requires multiple antimicrobial agents used for extended periods of time. The present study sought to evaluate the treatment success rate of bedaquiline- based regimens in MDR-TB patients. Methods: This was a systematic review and meta- analysis of studies published up to March 15, 2021. The pooled treatment success rates and 95% CIs were assessed with the fixed-effect model or the random-effects model. Values of p < 0.05 were considered significant for publication bias. Results: A total of 2,679 articles were retrieved by database searching. Of those, 29 met the inclusion criteria. Of those, 25 were observational studies (including a total of 3,536 patients) and 4 were experimental studies (including a total of 440 patients). The pooled treatment success rate was 74.7% (95% CI, 69.8-79.0) in the observational studies and 86.1% (95% CI, 76.8-92.1; p = 0.00; I² = 75%) in the experimental studies. There was no evidence of publication bias (p > 0.05). Conclusions: In patients with MDR-TB receiving bedaquiline, culture conversion and treatment success rates are high even in cases of extensive resistance. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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