| Autor: |
Santos, Ana Paula, Ribeiro-Alves, Marcelo, Corrêa, Raquel, Lopes, Isabelle, Almeida Silva, Mariana, Thomaz Mafort, Thiago, Leung, Janaina, Silva Rodrigues, Luciana, Rufino, Rogério |
| Předmět: |
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| Zdroj: |
Brazilian Journal of Pulmonology / Jornal Brasileiro de Pneumologia; mac/abr 2022, Vol. 48 Issue 2, p1-9, 9p |
| Abstrakt: |
Objectives: Pleural tuberculosis (PlTB) diagnosis is a challenge due to its paucibacillary nature and to the need of invasive procedures. This study aimed to identify easily available variables and build a predictive model for PlTB diagnosis which may allow earlier and affordable alternative strategy to be used in basic health care units. Methods: An observational cross-sectional study compared PlTB and non-TB patients followed at a tertiary Brazilian hospital between 2010 and 2018. Unconditional logistic regression analysis was performed and a Decision Tree Classifier (DTC) model was validated and applied in additional PlTB patients with empiric diagnosis. The accuracy (Acc), sensitivity (Se), specificity (Sp), positive and negative predictive values were calculated. Results: From 1,135 TB patients, 160 were considered for analysis (111 confirmed PlTB and 49 unconfirmed PlTB). Indeed, 58 non-TB patients were enrolled as controls. Hyporexia [adjusted odds ratio (aOR) 27.39 (95% CI 6.26 -- 119.89)] and cellular/ biochemical characteristics on pleural fluid (PF) (polimorphonuclear in two categories: 3-14% aOR 26.22, 95% CI 7.11 -- 96.68 and < 3% aOR 28.67, 95% CI 5.51 -- 149.25; and protein ≥ 5g/dL aOR 7.24, 95% CI 3.07 -- 17.11) were associated with higher risk for TB. The DTC constructed using these variables showed Acc=87.6%, Se=89.2%, Sp=84.5% for PlTB diagnosis and was successful ly appl ied in unconfirmed PlTB pat ients. Conclusion: The DTC model showed an excellent performance for PlTB diagnosis and can be considered as an alternative diagnostic strategy by using clinical patterns in association with PF cellular/biochemical characteristics, which were affordable and easily performed in basic health care units. [ABSTRACT FROM AUTHOR] |
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