| Autor: |
Zaman, Muhammad, Hassan, Rabia, Amjad, Muhammad Wahab, Khan, Sajid Mahmood, Raja, Maria Abdul Gaffor, Shah, Syed Sikandar, Siddique, Waqar, Aman, Waqar, Abid, Zahra, Butt, Muhammad Hammad |
| Zdroj: |
Pakistan Journal of Pharmaceutical Sciences; 2021 Supplement, Vol. 34, p2357-2364, 8p |
| Abstrakt: |
The current study was conducted to fabricate Metoclopramide HCL (MCH) and Sumatriptan succinate (SS) instant release buccal films (IRBF) without using any super disintegrant. The solvent casting method was used for the preparation of IRBFs and prepared IRBFs were physicochemically evaluated. Spectrophotometric analysis was done to determine the lambda max followed by the linearity determination of both drugs. Different concentrations such as 100, 125, and 150mg of hydrophilic polymer (HPMC E5) were employed but the concentration of glycerol was variable. Comparatively better results were observed for the formulation with 150mg of HPMC E5 and 30% glycerol. Formulated IRBFs showed good tensile strength with a mean disintegration time of 12.4-28.4 seconds and rapid dissolution with more than 50% drug release within 2 minutes. It was concluded that the chosen combination of polymers was appropriate for the fabrication of MCH and SS buccal strips. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
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