| Autor: |
Ukraintseva, Svetlana, Yashkin, Arseniy Pavlovich, Akushevich, Igor, Arbeev, Konstantin, Duan, Matt, Tropsha, Alex, Stallard, Eric, Yashin, Anatoliy |
| Zdroj: |
Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2021 Supplement S10, Vol. 17, p1-1, 1p |
| Abstrakt: |
Background: Diverse pathogens (viral, bacterial, fungal) were linked to Alzheimer's disease (AD) suggesting that compromised immunity may play role in AD. Chronic infections could be signs of weakened immune system favoring AD risk, while vaccines with beneficial off‐target effects might support immunity and protect against AD. Methods: We estimated effects of diagnosed herpes simplex, zoster (shingles), pneumonia, recurrent mycoses, and vaccinations against shingles and pneumonia, on AD onset in pseudorandomized sample of Health and Retirement Study participants aged 75+. Results: Herpesviruses and recurrent mycoses increased AD risk by 25%‐42%. Pneumococcal and shingles vaccines received between ages 65‐75 lowered consequent AD risk by 15%‐21%. Conclusion: Herpes and fungal infections increased AD risk, while vaccinations against shingles and pneumonia were protective, supporting the idea that AD is linked to compromised immunity rather than to specific microbe, and repurposing vaccines with beneficial off‐target effects on immune robustness/resilience might be useful for AD prevention. The study was supported by NIH grants 2RF1AG046860, 1R01AG062623 and 1R01AG063971. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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