Comparison of High-Flow Nasal Cannula and Noninvasive Ventilation in Acute Hypoxemic Respiratory Failure Due to Severe COVID-19 Pneumonia.

Autor:	Ramachandran Nair, Parvathy, Haritha, Damarla, Behera, Srikant, Athiphro Kayina, Choro, Maitra, Souvik, Kumar Anand, Rahul, Ranjan Ray, Bikash, Soneja, Manish, Subramaniam, Rajeshwari, Kumar Baidya, Dalim
Předmět:	INTENSIVE care units NASAL cannula RESPIRATORY insufficiency COVID-19 ACADEMIC medical centers CONFIDENCE intervals INTUBATION TIME CONTINUING education units DISEASE incidence TERTIARY care MANN Whitney U Test ARTIFICIAL respiration RANDOMIZED controlled trials HOSPITAL mortality T-test (Statistics) DESCRIPTIVE statistics CHI-squared test KAPLAN-Meier estimator SURVIVAL analysis (Biometry) STATISTICAL sampling REACTIVE oxygen species ODDS ratio DATA analysis software OXYGEN in the body LONGITUDINAL method
Zdroj:	Respiratory Care; Dec2021, Vol. 66 Issue 12, p1824-1830, 7p
Abstrakt:	BACKGROUND: Efficacy of high-flow nasal cannula (HFNC) over noninvasive ventilation (NIV) in severe coronavirus disease 2019 (COVID-19) pneumonia is not known. We aimed to assess the incidence of invasive mechanical ventilation in patients with acute hypoxemic respiratory failure due to COVID-19 treated with either HFNC or NIV. METHODS: This was a single-center randomized controlled trial performed in the COVID-19 ICU of a tertiary care teaching hospital in New Delhi, India. One hundred and nine subjects with severe COVID-19 pneumonia presenting with acute hypoxemic respiratory failure were recruited and allocated to either HFNC (n = 55) or NIV (n = 54) arm. Primary outcome was intubation by 48 h. Secondary outcomes were improvement in oxygenation by 48 h, intubation rate at day 7, and in-hospital mortality. RESULTS: Baseline characteristics and PaO2/FIO2 ratio were similar in both the groups. Intubation rate at 48 h was similar between the groups (33% NIV vs 20% HFNC, relative risk 0.6, 95% CI 0.31-1.15, P = .12). Intubation rate at day 7 was lower in the HFNC (27.27%) compared to the NIV group (46.29%) (relative risk 0.59, 95% CI 0.35-0.99, P = .045), and this difference remained significant after adjustment for the incidence of chronic kidney disease and the arterial pH (adjusted OR 0.40, 95% CI 0.17-0.93, P = .03). Hospital mortality was similar between HFNC (29.1%) and NIV (46.2%) group (relative risk 0.6, 95% CI 0.38-1.04, P = .06). CONCLUSIONS: We were not able to demonstrate a statistically significant improvement of oxygenation parameters nor of the intubation rate at 48 h between NIV and HFNC. These findings should be further tested in a larger randomized controlled trial. [ABSTRACT FROM AUTHOR]
Databáze:	Supplemental Index
Externí odkaz:	Zobrazit plný text záznamu