Risk Factors of Intractable Epilepsy in Children with Cerebral Palsy.
| Autor: | ABDEL MAKSOUD, Yehia Hamed, SULIMAN, Hany Abdelaziz, ElSAYED ABDULSAMEA, Sameh, MOHAMED KAMAL, Naglaa, AL-SHOKRAY, Ashraf Hamed, IBRAHIM, Asmaa Obada, ELSHORBAGY, Hatem Hamed, FATHALLAH, Mohamed Gamal El Din, ATTIA, Ahmed Mahmoud, ELSADEK, Akram Elshafey |
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| Předmět: |
EPILEPSY risk factors
MATERNAL health services BRAIN ANTICONVULSANTS ELECTROENCEPHALOGRAPHY ACQUISITION of data methodology RESEARCH methodology EPILEPSY NEONATAL diseases DRUG resistance CHILDREN with disabilities MAGNETIC resonance imaging RETROSPECTIVE studies CASE-control method GESTATIONAL age CEREBRAL anoxia-ischemia RISK assessment MEDICAL records DESCRIPTIVE statistics BIRTH weight CEPHALOMETRY CEREBRAL palsy SEIZURES (Medicine) COMPUTED tomography COGNITIVE testing APGAR score RECEIVER operating characteristic curves DISEASE complications SYMPTOMS CHILDREN |
| Zdroj: | Iranian Journal of Child Neurology; Autumn2021, Vol. 15 Issue 4, p75-87, 13p |
| Abstrakt: | Objectives We aimed to investigate the risk factors predicting the development of intractable epilepsy in children with cerebral palsy (CP), with an emphasis on perinatal characteristics, seizure semiology, imaging, and EEG findings. Materials & Methods Following a descriptive, retrospective, case-control design, 106 children with CP and epilepsy from 2015 to 2020 were studied (46 children with CP and intractable epilepsy and 60 with CP and controlled epilepsy). Data were retrieved from medical records of participants (i.e., demographics, clinical characteristics, perinatal history, etiology of seizure and CP, seizure semiology, intellectual functions, therapeutic options, brain imaging, and EEG findings). Results We established a model of the most important risk factors that can predict intractable epilepsy in children with CP. The model included the additive effect of a poor Apgar score at 5 minutes, the presence of neonatal seizures, focal epilepsy, and focal slowing on the EEG background (Area under the receiver operating characteristic of 0.810). Conclusion The findings can be used to identify intractable epilepsy in children who suffer from CP with further support by offering early therapeutic interventions intended to reduce the burden of refractory seizures. [ABSTRACT FROM AUTHOR] |
| Databáze: | Supplemental Index |
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