| Abstrakt: |
This article presents findings of a research previously published in the medical journal "Molecular Psychiatry," conducted by researcher Marcelo A. Chacon. According to this study, a beta-sheet breaker peptide prevents A-beta-induced spatial memory impairments with partial reduction of amyloid deposits. Current evidence supports the notion that beta-amyloid deposits or A-beta intermediates may be responsible for the pathogenesis in Alzheimer disease patients. In the present work, researchers have assessed the neuroprotective effect of the chronic intraperitoneal administration of a five-amino-acid beta-sheet breaker peptide on the rat behavioral deficit induced by the intrahippocampal A-beta-fibrils injection. |
