| Abstrakt: |
Background: Hepatocellular carcinoma (HCC) is an important health issue worldwide. Liver resection is the optimal management for early compensated HCC patients, but the majority of HCC patients are not candidates for resection. Several nonsurgical treatment modalities such as radio-frequency ablation (RFA), microwave ablation (MWA), trans-arterial chemoembolization, and immune therapy have been established. Intra-operative ultrasound (IOUS) is essential for accurate staging and secures both resection and RFA. We aimed to detect the value of using IOUS on safety margin and outcome during liver resection and RFA in the management of HCC patients. In the current study, 76 HCC patients, 58 males and 18 females, were included. Patients' age ranged from 49 to 69 years. Patients were divided into two groups: 52 open surgery liver resections (open resection group) and 24 laparoscopic-assisted RFA guided with laparoscopic IOUS (LARFA group). The open resection group was further subdivided into 32 cases for whom IOUS was performed and 20 patients studied retrospectively without IOUS. Surgical decisions were based on preoperative ultrasonography, computed tomography, and/or magnetic resonance imaging (MRI). We determined the size, number of lesions, and location by IOUS and compared them with preoperative imaging. Histopathology was done for resected lesions and follow-up CT for all patients. Results: In the open resection group, the 32 cases of 52 for whom IOUS was performed, all had free surgical margin (100%) while 18 of 20 patients studied retrospectively without IOUS had free surgical margin (90%). Patients operated guided by IOUS had less morbidity and mortality with less operative time and hospital stay. In the LARFA group (24 patients with 37 lesions), the one-month follow-up showed complete ablation for all lesions in the 24 patients, while 12-month follow-up proved two cases of recurrence. Conclusions: IOUS is a cornerstone in liver surgery. It improves outcomes with less morbidity and mortality and helps to achieve free surgical margin. Using IOUS allows the performance of radical but conservative hepatic resection. [ABSTRACT FROM AUTHOR] |
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