| Autor: |
Handajani, Juni, Tabtila, Urfa, Yunita, Swastiana Eka |
| Předmět: |
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| Zdroj: |
Journal of International Dental & Medical Research; 2021, Vol. 14 Issue 2, p629-632, 4p |
| Abstrakt: |
Sex hormones may affect keratinization of the epithelial cells. Cytokeratin 1 (CK1) is expressed in keratinized cells of oral mucosa. The aim is to analyze the effect of contraception on the CK1 expression of epithelial cells in the palatal mucosa and salivary estrogen. Forty females were divided equally into pill, injection, intrauterine device, and non-contraception (control) groups. Saliva samples were collected by unstimulated method. Salivary estrogen was measured by using an ELISA kit. Epithelial cells of the palatal mucosa were swabbed using cytobrush then treated by immunohistochemistry staining. The primary antibody of CK1 was used to analyze the expression of the protein. The results of ANOVA revealed the significant effect of contraception on salivary estrogen and CK1 expression (p < 0.05). The Games-Howell post hoc test indicated a significant difference between salivary estrogen level and CK1 expression among the control, pill, and injection groups (p < 0.05); however, no significant difference between the control and IUD groups (p > 0.05) was found. Pearson correlation analysis indicated a strong correlation between salivary estrogen and CK1 expression (r = 0.880). Hormonal contraception could increase the keratinization of epithelial cells by increasing CK1 expression and correlate with increasing salivary estrogen. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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