Adverse outcomes after preterm labor are associated with tumor necrosis factor-alpha polymorphism -863, but not -308, in mother-infant pairs.

Autor:	Amory, Josephine H., Adams, Kristina M., Ming-Tseh Lin, Hansen, John A., Eschenbach, David A., Hitti, Jane, Lin, Ming-Tseh
Předmět:	PREMATURE labor DURATION of pregnancy GENETIC polymorphisms PREGNANCY OBSTETRICS GYNECOLOGY ALLELES ANALYSIS of variance CHI-squared test FETAL diseases PREMATURE infants EVALUATION of medical care QUESTIONNAIRES RESEARCH funding TUMOR necrosis factors GENOTYPES KRUSKAL-Wallis Test
Zdroj:	American Journal of Obstetrics & Gynecology; Oct2004, Vol. 191 Issue 4, p1362-1367, 6p, 4 Charts
Abstrakt:	Objective: Two single-base polymorphisms of the tumor necrosis factor-alpha gene (TNF-alpha) at positions -863 and -308 are associated with variation in production of TNF-alpha (TNF-alpha). TNF-alpha genotypes were tested for association with adverse outcomes in mother-infant pairs with preterm labor.Study Design: We analyzed a cohort of 118 mother-infant pairs with preterm labor before 34 weeks' gestation. Polymerase chain reaction was used on extracted deoxyribonucleic acid for polymorphism assay. Outcomes included amniotic fluid TNF-alpha concentration, histologic chorioamnionitis, delivery gestational age, and composite neonatal morbidity. Statistical significance was determined by chi 2 and Kruskal-Wallis analysis of variance.Results: Mothers homozygous for the -863 polymorphism (AA) had significantly earlier deliveries ( P = .02), more chorioamnionitis ( P = .03), and greater composite neonatal morbidity ( P = .03). Neither maternal nor fetal carriage of the -308 polymorphism was associated with adverse outcome.Conclusion: In women with preterm labor before 34 weeks' gestation, maternal homozygous carriage of the -863 polymorphism may be associated with preterm delivery and adverse neonatal outcome. [ABSTRACT FROM AUTHOR]
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