Early Neurodevelopmental Outcome of Neonates with Gestation 35 Weeks or More with Serum Bilirubin in Exchange Range Without Encephalopathy: A Prospective Observational Study.
| Autor: | Sharma, Deepak, Harish, Rekha, Bhatti, Anuj, Uppal, Radhika, Naseem, Jehangir |
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| Předmět: |
EVOKED response audiometry
SCIENTIFIC observation NEONATAL intensive care HYPERBILIRUBINEMIA DEVELOPMENTAL disabilities GESTATIONAL age PATIENTS NEONATAL intensive care units FISHER exact test HOSPITAL admission & discharge T-test (Statistics) HEARING disorders DESCRIPTIVE statistics CHI-squared test DATA analysis software BILIRUBIN LONGITUDINAL method MOTOR ability |
| Zdroj: | Neonatal Network; Mar/Apr2021, Vol. 40 Issue 2, p66-72, 7p |
| Abstrakt: | Objective: To describe early neurodevelopment outcomes of neonates with severe hyperbilirubinemia without acute bilirubin encephalopathy (ABE). Methods: Neonates born at gestation ≥35 weeks, admitted to NICU with total serum bilirubin (TSB) in exchange range with no features of ABE, were followed up until the age of 6 months. Infants were assessed for impaired hearing and neurodevelopment at 3 months and 6 months of age. Results: A total of 59 neonates were enrolled in the study. At 3 months of age, 7.6 percent of neonates were found to have hypotonia and motor delay, whereas 42.3 percent had abnormal brainstem evoked response audiometery. At 6 months, 6.4 percent of neonates were found to have persistent neurodevelopmental impairment. Conclusion: Severe hyperbilirubinemia is associated with impaired neurodevelopment and hearing even in infants without ABE. Peak TSB level strongly correlates with abnormal outcomes. [ABSTRACT FROM AUTHOR] |
| Databáze: | Supplemental Index |
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