| Autor: |
Sasaki, Akihiro, Kato, Tatsuya, Ujiie, Hideki, Cho, Yasushi, Sato, Masaaki, Kaji, Mitsuhito |
| Zdroj: |
International Journal of Surgery Case Reports; Feb2021, Vol. 79, p431-435, 5p |
| Abstrakt: |
• Pulmonary lymphoepithelioma-like carcinoma (LELC) is extremely rare in Japan. • None of the studies regarding LELC in Japan described an association with PD-L1. • This is the first case of LELC in Japan with both expression of EBER-ISH and PD-L1. • An investigation of PD-L1 would be useful considering the PD-1/PD-L1 blockade. • Thus, PD-L1 expression should be examined in patients with pulmonary LELC. Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare type of non-small cell lung cancer (NSCLC) that is classified as a subtype of unclassified carcinoma by the WHO. LELC is usually associated with Epstein-Barr virus (EBV) infection. LELC has often been observed in Southeast Asia; however, it is extremely rare in Japan. A 60-year-old Japanese woman presented with an abnormal shadow in the left lung on chest radiography. Chest computed tomography showed a nodule located between the lingular and basal anteromedial segments. A blood test suggested an existing EBV infection, and LELC was suspected preoperatively in the transbronchial lung biopsy. She underwent a lingular and basal bi-segmentectomy. The EBV-encoded small ribonucleic acid in-situ hybridization (EBER-ISH) was positive, and she was diagnosed with LELC. Moreover, programmed death-ligand 1 (PD-L1) expression was moderately positive. No recurrence was observed for 30 months. Although LELC has been reported as a low-grade malignancy with a good prognosis, the frequency of PD-L1 expression in LELC seems to be higher than that in other NSCLCs. Moreover, it has been reported that LELC patients with high PD-L1 expression are likely to have early recurrence/metastasis and poor prognosis. An investigation of PD-L1 expression for LELC would be useful considering the benefit of PD-1/PD-L1 blockade in patients with pulmonary LELC with high PD-L1 expression. The present case is the first report of LELC with positive expression of EBER-ISH and PD-L1 in Japan. [ABSTRACT FROM AUTHOR] |
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