| Autor: |
Anongporn Nimboriboonporn, Norasate Samarnthai, Surat Phumphuang, Doonyapat Sa-nguanraksa, Thanawat Thumrongtaradol, Pornchai O-charoenrat |
| Zdroj: |
Thai Journal of Surgery; Apr-Jun2020, Vol. 41 Issue 2, p29-39, 11p |
| Abstrakt: |
Objectives: To evaluate risk factors for sentinel lymph node (SLN) metastasis and validate value of the Memorial Sloan-Kettering Cancer Center (MSKCC) nomogram for the prediction of sentinel lymph node metastasis in Thai breast cancer patients. Materials and Methods: Sentinel lymph node biopsy (SLNB) database containing 760 consecutive breast cancer patients was retrospectively analyzed. The predictive value of MSKCC nomogram was calculated by the trend line and the area under the receiver-operator characteristic curve. Meanwhile, predictors for SLN metastasis were also evaluated. Results: Tumor size, tumor type, tumor location, lymphovascular invasion, perineural invasion, multifocality, and progesterone receptor status were significant independent predictors for SLN metastasis (all p < 0.05). The MSKCC nomogram presented an area under the receiver-operator characteristic curve value of 0.73. Patients with predictive value less than 12% had a frequency of SLN metastasis of 0%. Those with values higher than 80% had a chance of SLN metastasis of 78.3%. Conclusions: The risk factors for SLN metastasis in our study were partly similar to those in the MSKCC nomogram. The MSKCC nomogram is a useful tool that could accurately predict the probability of SLN metastasis in our breast cancer patients. Axillary surgical staging might be avoided in patients with a predictive value of < 12% and axillary lymph node dissection (ALND) might be performed in those with a predictive value of > 80%, while other patients should still require SLNB. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
