| Autor: |
Dabitao, Djeneba, Dembele, Mamadou, Urbanowski, Michael, Kone, Bourahima, Wague, Mamadou, Coulibaly, Nadie, Sarro, Yeya dit Sadio, Baya, Bocar, Goita, Drissa, Dao, Sounkalo, Belson, Michael, Klein, Sabra L., Achenbach, Chad, Holl, Jane L., Diakite, Mahamadou, Doumbia, Seydou, Bream, Jay H., Bishai, William R., Diallo, Souleymane, Murphy, Robert L. |
| Zdroj: |
AIDS Research & Human Retroviruses; Jan2021, Vol. 37 Issue 1, p57-61, 5p |
| Abstrakt: |
It is now recognized that to fully understand the role of host genetic variation on susceptibility to HIV-1 infection, investigations must be extended to African populations. We sought to determine if genetic variation in IL10 are associated with HIV-1 infection in a West African cohort in Mali. HIV-infected and -uninfected individuals were genotyped for three common single nucleotide polymorphisms (SNPs) located at positions −592 (C/A), −819 (C/T), and −1082 (G/A) of the IL10 promoter. We found that the ATA haplotype, which has been previously associated with low IL-10 expression, was the most represented in the cohort. Although we observed a trend toward an increased frequency of ATA/ATA carriage in HIV-infected compared with -uninfected individuals, the difference was not statistically significant. Similarly, individual IL10 SNPs were not significantly enriched in the HIV-infected group, suggesting that IL10 genetic variants are not associated with HIV-1 in this West African cohort from Mali. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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