| Autor: |
Oo, Aung Myo, Adnan, Liyana Hazwani Mohd, Nor, Nasir Mat, Simbak, Nordin |
| Zdroj: |
International Medical Journal; Dec2020, Vol. 27 Issue 6, p670-673, 4p |
| Abstrakt: |
Objective: Lung Cancer has caused more deaths in developed and developing countries. The current therapeutic options available are more susceptible to adverse side effects, hence reducing their effectiveness in treating the disease. An immunomodulatory mechanism had been suggested with special emphasis on Natural Killer (NK) cells. In this review, a few alternatives had been suggested for lung cancer therapy including NK cell-based therapy and flavonoid compounds. The properties of flavonoids as anticancer agents have widely being studied but their roles in stimulating the innate immune system is scarce and limited. Hence, this article is written to reveal more insights on the alternative therapeutic options available for future consideration in lung cancer therapy. Methods: All of the recently published articles from year 2003 to 2020 had been searched and reviewed from google scholar, scopus and pubmed databases. The main keywords used were lung cancer, flavonoids and NK cells. Only relevant articles that fulfilled the searched criteria had been included in this review. Conclusion: It was found that flavonoids from flavones and flavonol groups were extensively studied in lung cancer therapy but their roles in NK cells growth stimulating activity need to be established further for their immunomodulatory properties. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
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