| Autor: |
Navalkele, B.D., Polistico, J., Sandhu, A., Awali, R., Krishna, A., Chandramohan, S., Tillotson, G., Chopra, T., Navalkele, Bhagyashri D, Polistico, Jordan, Sandhu, Avnish, Awali, Reda, Krishna, Amar, Chandramohan, Suganya, Tillotson, Glenn, Chopra, Teena |
| Zdroj: |
Journal of Hospital Infection; Dec2020, Vol. 106 Issue 4, p643-648, 6p |
| Abstrakt: |
Background: Recurrent Clostridioides difficile infection (CDI) is one of the most common and challenging infections to treat in healthcare facilities. Faecal microbiota transplantation (FMT) is recommended as a definitive treatment option.Methods: We performed a retrospective review of 50 patients from January 2015 to December 2019 who underwent FMT for recurrent CDI. Primary outcome was recurrence of CDI within 12-weeks of FMT and secondary outcomes were the need for repeat FMT, serious adverse outcomes related to FMT and all-cause mortality.Results: Fifty charts were reviewed, of which 47 cases comprising 17 immunocompromised patients treated with FMT via retention enema were included in the study. The majority of the patients had ≥3 recurrent CDIs (62%). Nine (19%) patients failed to respond to the first FMT and five underwent repeat FMT within four to 12 weeks. The cure rate was 81% after the first FMT (38/47) and 91% after the second FMT treatment (43/47). Serious adverse events occurred in 2% and all-cause mortality was 2% at 90-day follow up.Conclusion: Our study demonstrated the safety and efficacy of FMT administered via retention enema, a simple bedside procedure, for the treatment and prevention of recurrent non-severe and severe CDI with an overall cure rate of 91%. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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