| Autor: |
Llano López, Luis H., Melonari, Pablo, Olguin, Marisa, Fraile, Miriam Débora, Landa, Adriana I., Gargiulo, Pascual A. |
| Předmět: |
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| Zdroj: |
Journal of Basic & Clinical Physiology & Pharmacology; Nov2020, Vol. 31 Issue 6, p1-6, 6p |
| Abstrakt: |
Background: In previous studies, we have observed that glutamate antagonists injected within the nucleus accumbens septi (NAS) induced an anxiolytic-like effect in the elevated plus maze (EPM) test in rats. In the present study, the effect of Atenolol, a specific Beta Adreno-receptor antagonist in the EPM was studied in male rats bilaterally cannulated NAS. Methods: Rats were divided into five groups that received either 1 μL injections of saline or atenolol in different doses (0.75, 1 or 2 μg/1 μL, n=15–16) 15 min before testing. Results: Time Spent in the Open Arm was modified by treatment (F=4.563, p=0.006, df 3). This was increased by the lowest dose of atenolol (p<0.05), by the medium doses (p<0.001) and also by the highest dose (p<0.01). Time per Entry was modified by treatment (F=4.54, p=0.06, df 3). This parameter was increased by the lowest dose of atenolol (p<0.01), but not for the medium and higher doses. Conclusions: We conclude that Atenolol beta receptor blockade in the accumbens lead to an anxiolytic-like effect related to an increase in the time spent in the open arm and in the time per entry, showing specific behavioral patterns. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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