| Autor: |
D.-M. MA, D. SUN, J. WANG, D.-H. JIN, Y. LI, Y.-E. HAN |
| Zdroj: |
European Review for Medical & Pharmacological Sciences; 2020, Vol. 24 Issue 5, p2616-2624, 9p |
| Abstrakt: |
OBJECTIVE: The regulatory mechanism of lncRNA MIR4435-2HG has been extensively investigated in human cancers other than melanoma. This study aims to elucidate the role of lncRNA MIR4435-2HG in melanoma. MATERIAL AND METHODS: The mRNA expression was detected by RT-qPCR. MTT assay, Transwell assay and Dual-Luciferase reporter assay were used to investigate the regulatory mechanism of lncRNA MIR4435-2HG. RESULTS: Upregulation of lncRNA MIR4435-2HG was identified in melanoma and promoted melanoma cell proliferation, migration and invasion. In addition, lncRNA MIR4435-2HG serves as the ceRNA of miR-802. MiR-802 inhibited melanoma progression by downregulating lncRNA MIR4435-2HG. Besides, miR-802 directly targets FLOT2. And knockdown of FLOT2 restrained the progression of melanoma by downregulating lncRNA MIR4435-2HG and upregulating miR-802. CONCLUSIONS: LncRNA MIR4435-2HG promotes cell proliferation, migration and invasion in melanoma by sponging miR-802 and upregulating FLOT2. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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