| Autor: |
Yansen Cui, Tingfen Huang, Ziran Wang, Guangjian Zhao, Mei Zheng, Zhongrong Cheng |
| Zdroj: |
International Journal of Gerontology; Sep2019, Vol. 13 Issue 3, p231-234, 4p |
| Abstrakt: |
Background: To evaluate the efficacy and safety of intravenous thrombolytic therapy (TT) using low-dose rt-PA in a broadened therapeutic window (TW) for ischemic stroke treatment under multimode magnetic resonance imaging (MRI) monitoring. Methods: A total of 45 patients with ischemic stroke occurring within 4.5-6 h prior to treatment were divided into two groups: thrombolytic group (Group A) and non-thrombolytic group (Group B). Another set of 25 patients with ischemic stroke occurring within 4.5 h were classified into Group C. Low-dose rt-PA was administered in Group A, standard-dose rt-PA in Group C, and normal therapy in Group B. All the patients were evaluated using the National Institutes of Health Stroke Scale (NIHSS) scores before and 24 h after treatment and modified Rankin scale (mRS) scores 90 days after treatment. Results: The post-treatment NIHSS score and day-90 mRS score in Groups A and C were significantly different from those in Group B (p < 0.05). Conclusion: Intravenous TT using low-dose rt-PA in a broadened TW for ischemic stroke treatment under multimode MRI monitoring is safe and effective. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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