| Autor: |
Hamdaoui, Houari, Aouar, Amaria, Belkhatir, Djamel, Moussouni, Abdellatif, Moqaddem, Zakarya, Khater, Sarra |
| Předmět: |
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| Zdroj: |
Journal of International Dental & Medical Research; 2020, Vol. 13 Issue 1, p201-208, 8p, 3 Charts, 2 Graphs |
| Abstrakt: |
Down Syndrome (DS) is the most common chromosomal aberration in humans, associated with several conditions. The aim of our study is to describe the main comorbidities associated with DS at the school-age, with the cytogenetic profile and contributed risk factors. A 7-year retrospective, descriptive study was carried out from 2010 to 2017, based on the psychoeducational centers for mental health (CPPs, UDM and ANIT) in Tlemcen. Data collected using a pre-established questionnaire for DS parents and referring to children's medical and administrative records. Among 207 patients with DS, 36 were identified with cytogenetic study, 97.22% were free trisomy, 2.78% mosaic and no translocation's cases. The sex ratio (M:F) was 1.58 :1 and the median age was 11.7 years. The main age of DS mothers was 36.32 years. Of the 133 individual with clinical morbidities, the most common was ophthalmologic (20%), ENT (24.06%) and CHD defect (16.92%), followed by thyroid (9.23%), gastroenterological (9.23%) and CNS disorders (9.23%). No associations were found between maternal age or parental consanguinity and risks of congenital conditions. Risk of developing CHD, Refraction disorders or also Epileptic seizures increase with age. Children with DS have several DS-specific morbidities. Advanced maternal age is one of major risk factors for giving birth to a child with DS. The prevalence of clinical comorbidities in our population was significantly lower than others of literature, because of the younger age of sample study, and the selective nature of psychoeducational centers. [ABSTRACT FROM AUTHOR] |
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