| Autor: |
DENG Yunxia, LEU Minyan, WANG Lu, BIAN Yonggang, SHAO Zhiyu |
| Předmět: |
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| Zdroj: |
Journal of Donghua University (English Edition); Feb2020, Vol. 37 Issue 1, p35-42, 8p |
| Abstrakt: |
Bakuchiol isolated from Psoralea corylifolia is a naturally occurring prenylated phenolic monoterpene with a variety of bioactivities. The aim of this study was to improve the water solubility and thermal stability of bakuchiol through complexing it with hydroxypropyl-β-cyclodextrin (HP-β-CD). The bakuchiol/HP-β-CD inclusion complex's behavior and characterization were investigated by ultraviolet-risible (UV-vis) spectroscopy, Fourier transform infrared spectroscopy (FT-IR), thermograrimetric analysis (TGA), X-ray diffraction (XRD),1 H nuclear magnetic resonance(NMR), and two-dimensional (2D) NMR. The obtained results indicated the formation of 1 : 1 inclusion complex for bakuchiol with HP-β-CD. Water solubility of bakuchiol was significantly improved by complexation with HP-β-CD as demonstrated by phase solubility studies. The encapsulation of bakuchiol w'as confirmed by UV-ris, FT-IR, and XRD. The thermal stability was effectively enhanced by TGA and derivative thermograrimetry (DTG) analysis. In vitro antioxidant activity showed that bakuchiol/HP-β-CD inclusion complex had a little higher antioxidant ability than free bakuchiol. Moreover, we got the possible inclusion mode for the bakuchiol/HP-β-CD inclusion complex through NMR analysis. These results suggest that the inclusion complex can be a potentially useful approach in the design of novel formulations of bakuchiol for medical applications. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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