| Abstrakt: |
• Three new triterpene glycosides, mussapilosides A–C (1 - 3) were isolated from Mussaenda pilosissima Valeton. • The structures were successfully determined by spectroscopic evidence. • Compounds 2 , 6 , and 8 strongly inhibited PTP1B enzyme with the IC 50 values ranging of 3.4 ∼ 6.4 μM. Three new triterpene glycosides, mussapilosides A–C (1 - 3) together with six known triterpene glycosides, cincholic acid-28- O - β - d -glucopyranosyl ester (4), mussaendoside S (5), quinovic acid 28- O - β - d -glucopyranosyl ester (6), glycoside A (7), glycoside B (8), and quinovic acid 3- O - β - d -glucopyranosyl(1→2)- β - d -glucopyranoside (9) were isolated from the leaves of Mussaenda pilosissima. Their chemical structures were elucidated on the basis of extensive spectroscopic methods, including 1D, 2D NMR, and HR ESI MS spectra. All these compounds were examined for their inhibitory activity against PTP1B. The results indicated that compounds 2 , 6 , and 8 exhibited potent inhibitory effects with IC 50 values of 3.4 ± 0.2, 4.2 ± 0.2, and 6.4 ± 0.2 μM, respectively. Compound 5 showed the moderate inhibitory effect with IC 50 value of 63.0 ± 3.2 μM. [ABSTRACT FROM AUTHOR] |
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