| Autor: |
Krishna, Yamini, White, Jessica, Sinha, Tapati, Bakshi, Arti |
| Zdroj: |
Diagnostic Histopathology; Mar2020, Vol. 26 Issue 3, p143-146, 4p |
| Abstrakt: |
Hyperkeratosis lenticularis perstans (Flegel disease) is a rare, benign hyperkeratotic skin disorder which typically occurs in lower extremities of Caucasian middle-aged patients. Most cases are sporadic although familial cases with an autosomal dominant mode of inheritance have been reported.1–5 Clinically the condition mimics many other hyperkeratotic and inflammatory disorders and the diagnosis is only confirmed on histopathological and clinical correlation.2,5,6 The condition typically presents with asymptomatic keratotic/scaly red/brown papules which histomorphologically show lamellar hyperkeratosis with abrupt peripheral basket-weave orthokeratosis, irregular acanthosis and underlying lichenoid lymphocytic infiltrate.1–7 The pathogenesis remains unclear and thus various topical and/or systemic treatments have shown variable success rates. Herein we describe a classical case with review of the current literature. [ABSTRACT FROM AUTHOR] |
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