| Autor: |
Oluboyo, A. O., Onodjohwo, E. F., Oluboyo, B. O., Ukaegbu, H. C. |
| Zdroj: |
International Medical Journal; Feb2020, Vol. 27 Issue 1, p16-20, 5p |
| Abstrakt: |
Background: Young children are especially vulnerable to severe malaria and oxidative stress resulting from the effects of the malaria which may contribute to greater population of malaria deaths. Objectives: To evaluate selected antioxidant enzymes (serum glutathione peroxidase and superoxide dismutase) levels and determine their relationship with other parameters in malaria infested subjects. Study design: The study was designed to evaluate selected antioxidants in children (both males and females) between the ages of 6 months to 15 years old who were tested positive for Plasmodium falciparum malaria, either presenting with severe malaria or uncomplicated malaria but without cerebral malaria. Methods: A total of ninety (90) children were recruited; 30 had severe malaria, 40 had uncomplicated malaria and 20 were control subjects. Blood samples were collected for the detection of malaria parasites, malaria parasite density, packed cell volume (PCV), haemoglobin and total white cell counts (WBC) using conventional methods. Glutathione peroxidase and superoxide dismutase were analyzed using Enzyme immunoassay technique. Results: Severe malaria showed significant decrease (p < 0.05) in PCV, Heamoglobin, Glutathione peroxidase and Superoxide dismutase compared with uncomplicated and control subjects. There was significant increase (p > 0.05) in total white cell counts and malaria parasite density in those who had severe malaria. Glutathione peroxidase and Superoxide dismutase showed significant positive correlation in both severe and complicated malaria but not with other parameters. Conclusion: There was significant decrease in the levels of Glutathione peroxidase and superoxide dismutase in high parasitaemia. The significantly low antioxidant enzyme levels in severe malaria subjects are a pointer to the fact that these antioxidants are used up in combating the effects of oxidative stress as a result of the malaria. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
