Effect of different levels of dietary methionine restriction on relieving oxidative stress and behavioral deficits in middle-aged mice fed low-, medium-, or high-fat diet.

Autor: Wu, Guoqing, Han, Le, Shi, Yonghui, Feng, Chuanxing, Yan, Biao, Sun, Jin, Tang, Xue, Le, Guowei
Zdroj: Journal of Functional Foods; Feb2020, Vol. 65, pN.PAG-N.PAG, 1p
Abstrakt: • MR attenuated behavioral deficits in a dose-dependent manner in middle-aged mice. • The benefits of regulating oxidative stress and improving behavioral deficits of 60% MR (MR60) were more evident in high-fat-diet mice than those in low- or medium-fat-diet mice. • The mechanism of MR may be associated with an improvement of thyroid function. Dietary methionine restriction (MR) could prevent age-related diseases and extend lifespan. The present study compared the effects of different levels of MR on oxidative stress and behavioral deficits in middle-aged mice fed a diet with various contents of fat. C57BL/6J middle-aged male mice were divided into nine groups with various combinations of dietary fat (low, medium, and high) and MR (0%, 60%, and 80%). MR attenuated dietary fat-induced oxidative stress and anxiety; improved athletic ability, learning, memory, and cognitive ability in conjunction with an improved thyroid function in a dose-dependent manner. Moreover, the beneficial effect of MR60 was prominent in middle-aged mice fed a HF diet relative to the corresponding MR0 group. These results provide more information on the appropriate methionine content to design personalized nutritional diets. [ABSTRACT FROM AUTHOR]
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