| Autor: |
Suprianto, Kosno, Murdiastuti, Kwartarini |
| Předmět: |
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| Zdroj: |
Journal of International Dental & Medical Research; 2019, Vol. 12 Issue 4, p1268-1273, 6p, 7 Charts |
| Abstrakt: |
Platelet-Rich Plasma (PRP) has been found to be a delivery system of essential growth factors. The collagen is an activator that causes clotting of the PRP and stimulates growth factor release from the platelets and granulocytes. The effectiveness of growth factors in PRP can enhance the migration of fibroblast in the phase of proliferation, which are involved in the healing of periodontal tissues. The research aim was to investigate the activation effect of PRP using collagen for the migration of fibroblast in the periodontal ligament. The PRP from the human donor was activated using collagen (collagen-activated PRP) and compared with inactived PRP (control group). The migration of fibroblast was measured after a half, one, two, and three days. The collagen-activated PRP resulted in a more significant migration of fibroblast compared with the inactivated PRP. Substantial differences in fibroblast migration were observed after a half, one, two, and three days. Collagen-activated PRP can be used as an alternative to stimulate platelet-associated growth factors and result in greater fibroblast migration. Polypeptide growth factors (PDFs) are biological mediators in periodontal regeneration. Platelet-derived growth factor and transforming growth factor-β are the most potent stimulators of PGF for the migration of fibroblast. It is vital in the process of wound healing. The outcome of this research is Platelet-Rich Plasma could improve the activity of the fibroblast migration, and the addition of a Collacure collagen on the PRP affected the migration of periodontal ligament fibroblast. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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