| Autor: |
Arumugam, Ganeshkumar, Rajendran, Rajaram, Khaleelullah, Nasreen Syed, Ramanathan, Sharmila |
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| Zdroj: |
Biocatalysis & Agricultural Biotechnology; Jul2019, Vol. 20, pN.PAG-N.PAG, 1p |
| Abstrakt: |
Candidiasis in the genital region induces serious infections that can be faced by sexually active women worldwide. Especially, the therapeutic failure of Candida species in the past decades has garnered significant research focus. In this study, we investigated the anti microbial activities of six different seaweeds (red, green and brown) were collected from the Gulf of Mannar region using well diffusion and micro dilution technique. An average zone of inhibition obtained were ranged frim 0 to 17 mm. Among the different seaweeds, the methanol extract of Dictyota bartayresiana was more susceptible (17.4±0.62 mm) and Chaetomorpha sp was least effective (12.29±0.99 mm) against Candida albicans. However, the zones of inhibition of methanolic extract of seaweeds were several folds higher than the fluconazole. Micro dilution and time dependent kinetics studies revealed that all the seaweeds have only moderate activity towards C. albicans and MFC/MIC show less than 4 for all tested extracts. Conversely, DCM extract of Turbinaria ornata showed minimum inhibitory for Candida biofilm. The results clearly confirmed that all the extract represent the fungistatic mechanism of inhibition rather than fungicidal except amphotericin B, suggesting that instead of using seaweed extract for killing C. albicans better to use to prevent their virulence property. [ABSTRACT FROM AUTHOR] |
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