| Autor: |
Romero, Roberto, Chaiworapongsa, Tinnakorn, Kuivaniemi, Helena, Tromp, Gerard |
| Předmět: |
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| Zdroj: |
American Journal of Obstetrics & Gynecology; Jun2004, Vol. 190 Issue 6, p1509-1519, 11p, 2 Charts |
| Abstrakt: |
This issue of the Journal contains a report stating that a "gene-environment interaction" determines risk for preterm birth. The importance of this observation was recognized with a Research Excellence Award by the Society for Maternal-Fetal Medicine and represents a major contribution by the team of Dr George Macones and Dr Jerome Strauss III at the University of Pennsylvania. Gene-environment interactions are central to the understanding of common complex diseases such as atherosclerosis, obesity, hypertension, depression, etc. Screening for bacterial vaginosis and treatment has been considered a strategy to reduce the rate of preterm birth. Yet, there is much controversy surrounding the issue. This Clinical Opinion will review key concepts of bacterial vaginosis, vaginal inflammation, the importance of genetic control of the inflammatory response in the context of microbial invasion, and the significance of the report of Dr Macones et al contained in the current issue of the Journal. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
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