| Autor: |
Al-Bayaty, Fouad Hussain, Ibrahim, Omar Emad, Kutty, Methil Kannan, Binti Harun, Farah Fadzreen, Binti Selamat, Siti Amanani, Bin Adam, Mohd Noor Arif, Jamil Al-Obaidi, Mazen M. |
| Předmět: |
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| Zdroj: |
Journal of International Dental & Medical Research; 2019, Vol. 12 Issue 2, p389-395, 7p, 5 Diagrams, 2 Graphs |
| Abstrakt: |
The aim of this study was to determine whether oral challenged with Porphyromonas gingivalis (P. gingivalis) mimicking periodontitis-associated with central nervous system (CNS) inflammatory lesions in rabbit. Rabbits were divided into two groups, Group1 as control group and Group2 as experimental group, the rabbits in Group2 continuously challenged orally with P.gingivalis five times a week for 12 weeks. The whole brain taken out carefully. Abnormal changes that seen grossly were recorded. Samples were then sectioned into serial specimens and stained with H&E stain to evaluate the histopathological changes inside the brain. Blood sample were taken from each group to be tested for brain derived neurotrophic factor (BDNF) level. The maxilla and mandible were separated from the remaining skull and defleshed. Alveolar bone loss was evaluated morphometrically by using cone beam computed tomography (CBCT). The gross pathology of the experimental group showed brain oedema, cerebral vascular congestion and haemorrhage. Histological analysis of infected group with P. gingivalis showed lesions in the cerebral cortex & meninges, with perivascular cuffing. Non-caseating granuloma observed in the cerebral cortex. BDNF level in experimental group appears to be higher as compared to the control group. CBCT images demonstrated significantly higher alveolar bone loss in infected group compared to the control group. The present study provides evidence that infection with a periodontal pathogen, considered as primary culprit of periodontal disease P. gingivalis may play a role in the pathogenesis of CNS inflammatory disorders. [ABSTRACT FROM AUTHOR] |
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