The effects of a low-dose monophasic preparation of levonorgestrel and ethinyl estradiol on coagulation and other hemostatic factors.

Autor:	Archer, D F, Mammen, E F, Grubb, G S
Předmět:	ESTROGEN replacement therapy PROTEIN analysis STEROID drugs FIBRINOLYTIC agents BLOOD coagulation BLOOD coagulation factors BLOOD proteins COMBINATION drug therapy COMPARATIVE studies CONTRACEPTIVE drugs DOSE-effect relationship in pharmacology ESTROGEN HEMOSTASIS RESEARCH methodology MEDICAL cooperation ORAL contraceptives RESEARCH STEROIDS EVALUATION research FIBRIN fibrinogen degradation products LEVONORGESTREL THERAPEUTICS
Zdroj:	American Journal of Obstetrics & Gynecology; Nov99 Part 1 of 2, Vol. 181 Issue 5, p63-66, 4p
Abstrakt:	Objective: This study was undertaken to evaluate the effects on hemostatic factors of a low-dose preparation of levonorgestrel and ethinyl estradiol in a 12-cycle study.Study Design: Thirty healthy women began taking 100 microg levonorgestrel and 20 microg ethinyl estradiol on the first day of the menstrual cycle, continued to take the preparation for the next 21 days, and then took placebo for 7 days. Mean changes in prothrombin time, partial thromboplastin time, and levels of factors VII and X, antithrombin, plasminogen, fibrinogen, protein S, thrombin-antithrombin complexes, and D-dimer were analyzed at baseline and at cycles 3, 6, and 12 with paired Student t tests.Results: Factor X, plasminogen antigen and activity, and D-dimer levels were significantly increased (P Conclusion: The effects on hemostatic factors in healthy women of a monophasic preparation of 100 microg levonorgestrel and 20 microg ethinyl estradiol were similar to those of other low-dose oral contraceptives. [ABSTRACT FROM AUTHOR]
Databáze:	Supplemental Index
Externí odkaz:	Zobrazit plný text záznamu Full Text from ScienceDirect