| Autor: |
Bardeguez, A D, Skurnick, J H, Perez, G, Colon, J M, Kloser, P, Denny, T N |
| Předmět: |
|
| Zdroj: |
American Journal of Obstetrics & Gynecology; Jan97 Part 2 of 2, Vol. 176 Issue 1, p158-165, 8p |
| Abstrakt: |
Objective: Our purpose was to describe the lymphocyte subpopulations in genital tract samples from human immunodeficiency virus-infected women and the clinical correlates associated with lymphocyte shedding.Study Design: Genital tract samples of women infected with human immunodeficiency virus-1 were processed for immunophenotyping analysis with a FACScan flow cytometer. Immunologic and virologic characteristics of women with and without lymphocyte shedding were compared with t test, Wilcoxon rank test, or Fisher's exact test.Results: The rate of genital lymphocyte shedding among human immunodeficiency virus-1-infected women was 39%. Genital shedding was not related to age, race, use of antiretroviral therapy, or positive human immunodeficiency virus-1 culture. A negative rank correlation (r = -0.71, p = 0.047) between CD3+ CD4+ counts in peripheral blood and genital tract was observed. The majority of the lymphocyte cells were CD3+ CD8+, and > 80% of the CD3+ CD4+ cells were memory cells.Conclusion: The immune profile of the genital tract lymphocytes is suggestive of a local mucosal immune response. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full Text from ScienceDirect