Reduced FEV1/FVC and FEV1 in the Normal Range as a Physiological Variant.

Autor:	dos Santos Andreata, Luciana, Soares, Maria Raquel, Pereira, Carlos A. C.
Předmět:	FORCED expiratory volume LUNG physiology ANALYSIS of variance ANTHROPOMETRY ASTHMA CHI-squared test FISHER exact test LONGITUDINAL method OBSTRUCTIVE lung diseases SCIENTIFIC observation QUESTIONNAIRES RESPIRATORY measurements PULMONARY function tests RESPIRATORY obstructions SPIROMETRY STATISTICS LOGISTIC regression analysis DATA analysis VITAL capacity (Respiration) CASE-control method RECEIVER operating characteristic curves
Zdroj:	Respiratory Care; May2019, Vol. 64 Issue 5, p570-575, 6p, 2 Charts, 1 Graph
Abstrakt:	BACKGROUND: Healthy individuals without respiratory symptoms can sometimes present with low FEV1/FVC. The objective of this study was to characterize and compare subjects without symptoms and with reduced FEV1/FVC but normal FEV1 with subjects with mild obstructive lung disease. METHODS: Fifty healthy subjects with FEV1/FVC below the fifth percentile of reference values (normal variants) were compared with 52 subjects with asthma and 48 subjects with COPD who had similar FEV1/FVC. RESULTS: Subjects without symptoms were more likely to be male, younger, and taller, and to have higher FVC%, FEV1%, mid expiratory flow, and terminal flow than subjects with obstructive disease. A receiver operating characteristic curve analysis determined that the best separation between the groups was provided by age < 55 y, height ≥ 167 cm, and FVC > 105%. A logistic regression analysis confirmed that male sex, age, FVC%, and FEF75 (Forced expiratory flow in 75% of forced vital capacity) were significant factors for discriminating subjects without symptoms from those with obstructive lung disease. CONCLUSIONS: A reduced FEV1/FVC may be a normal finding in younger-to-middle age male subjects with an FVC% value above the mean predicted value, especially when terminal flow is within the normal range. [ABSTRACT FROM AUTHOR]
Databáze:	Supplemental Index
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