| Autor: |
Juviler, Peter G., Patel, Ankit P., Qi, Yanjie |
| Zdroj: |
International Journal of Surgery Case Reports; 2019, Vol. 55, p50-53, 4p |
| Abstrakt: |
Highlights • Hidradenitis suppurativa is a morbid disease and can resist medical management. • Squamous cell carcinoma may develop within a chronic hidradenitis suppurativa lesion. • Early surgical intervention with skin grafting offers relief from disease morbidly. • Early skin grafting eliminates risk of untreatable cancer discovery. Abstract Introduction Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the skin that has potential for malignant transformation into squamous cell carcinoma (SCC). The pathogenesis of HS is poorly understood but thought to be from follicular keratinization, occlusion, and rupture of the pilosebaceous unit, followed by an infiltration of inflammatory cells into the dermis. Treatment is challenging due to a lack of effective medical therapies. Presentation of case In this case report, we describe a patient with chronic HS that developed into SCC who underwent late surgical intervention after failing medical management. At the time malignant transformation was discovered, the SCC was beyond resectability and ultimately fatal. Discussion Based on the morbidity and mortality of chronic HS illustrated in our case and presented in the literature, we advocate for early surgical intervention. Conclusion Wide surgical excision offers a near definitive intervention and should at least be considered for all chronic HS patients due to high morbidity and malignant transformation risk. [ABSTRACT FROM AUTHOR] |
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